Molecular Weight: 2174.64 Da | 16 Amino Acids | Form: Lyophilized | Purity: 99%+ HPLC
MOTS-c is a mitochondria-derived peptide (MDP) of 16 amino acids that is uniquely synthesized within the mitochondria and translocates to the nucleus, where it is studied for regulating genes tied to energy metabolism and cellular stress. In preclinical and in-vitro research, MOTS-c is documented for AMPK activation, glucose uptake, fat oxidation, and mitochondrial-function studies — making it a leading compound in metabolic, exercisephysiology, and longevity research. Each vial contains 10mg of lyophilized MOTS-c at 99%+ HPLC-verified purity, with a batch-specific Certificate of Analysis available for download. *
MOTS-c
Mitochondria-derived peptide
Mechanism of Action• AMPK Activation: Activates the AMPK pathway, increasing glucose uptake and regulating energy metabolism in muscle-tissue models.
• Nuclear Gene Regulation: Translocates to the nucleus under metabolic stress and influences expression of genes tied to metabolism and antioxidant defense.
• Lipid & Glucose Metabolism: Studied for brown-fat activation, fat oxidation, and insulin-sensitivity in metabolic models.
| Compound | MOTS-c (Mitochondria-derived peptide) |
| Sequence | MRWQEMGYIFYPRKLR |
| Amino Acids | 16 |
| Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| MW | 2174.64 g/mol |
| CAS Number | 1627580-64-6 |
| Purity | ≥ 99% HPLC |
| Identity | LC-MS Verified |
| Form | Lyophilized powder |
| Vial Size | 3mL glass vial · 10mg / 40mg |
| Additives | None |
| Batch COA | Available for download |
- Metabolic-disorder & metabolic-syndrome models
- Exercise-physiology & muscle-metabolism research
- Fat-metabolism & adipose-tissue research
- Insulin-sensitivity & glucose-homeostasis studies
- Longevity & aging research
- Mitochondrial-medicine & cellular-stress-response research
Storage: Store lyophilized powder at -20°C long term; once reconstituted, store at 4°C, protect from light and moisture.
Handling: Research use only; handle by licensed, qualified professionals with PPE. Reconstitution chemistry is the sole responsibility of the receiving research institution.
FEATURED INGREDIENTS
All Ingredients
Mitochondria-Derived
A rare peptide encoded within mitochondrial DNA (12S rRNA / MT-RNR1) — one of the few known mitochondrial-derived peptides.
AMPK Activation
Studied for switching on AMPK, the cell’s master regulator of energy metabolism.
Metabolic Regulation
Researched across glucose uptake, fat oxidation, and insulin sensitivity pathways.
PRODUCT BENEFITS
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Mitochondria-Derived Peptide A 16-amino-acid peptide synthesized within mitochondria that translocates to the nucleus to regulate metabolic gene expression — a unique tool for mitochondrial research.
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AMPK Activation & Glucose Uptake Studied for activating the AMPK pathway and enhancing glucose uptake in muscle-tissue models.
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Fat Oxidation & Brown-Fat Research Examined for stimulating brown-fat activation and favoring fat oxidation over storage.
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Insulin-Sensitivity Studies Low MOTS-c correlates with insulin resistance in models; researched for glucose-metabolism support.
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Longevity & Mitochondrial Function MOTS-c declines with age and is linked in genetic studies to exceptional longevity; studied for mitochondrial protection.
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99%+ HPLC-Verified Purity Independently verified by third-party labs via HPLC and LC-MS; batch-specific COA and SDS available pre-purchase.
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MOTS-c is a mitochondria-derived peptide encoded within the 12S rRNA region (MT-RNR1). Under metabolic stress it activates the AMPK pathway and translocates to the nucleus, where it is studied for regulating genes tied to energy metabolism, glucose uptake, fat oxidation, and antioxidant defense.*
WHAT TO EXPECT
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
16-Amino-Acid Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg — a short, stable peptide ideal for metabolic and mitochondrial research models.
Mitochondrial Origin
Encoded within the mitochondrial genome (12S rRNA, MT-RNR1) rather than the cell nucleus — a defining feature of mitochondrial-derived peptides.
AMPK Pathway Target
Acts through the AMPK energy-sensing pathway, the same master switch studied in exercise physiology and longevity research.
ALL DETAILS
- 16-Amino-Acid Sequence — Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg — a short, stable peptide ideal for metabolic and mitochondrial research models.
- Mitochondrial Origin — Encoded within the mitochondrial genome (12S rRNA, MT-RNR1) rather than the cell nucleus — a defining feature of mitochondrial-derived peptides.
- AMPK Pathway Target — Acts through the AMPK energy-sensing pathway, the same master switch studied in exercise physiology and longevity research.
The "MOTS-c" Peptide |
No fillers | No artificial additives | No excipients | 99%+ HPLC verified · batch COA | No repackaged imports | No human-use claims |
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MOTS-c Peptide
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Other Peptide |
The "MOTS-c" Peptide
| Compare to: |  MOTS-c Peptide |
Other Peptide |
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| No fillers | ||
| No artificial additives | ||
| No excipients | ||
| 99%+ HPLC verified · batch COA | ||
| No repackaged imports | ||
| No human-use claims |
FAQs
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring copper-binding tripeptide studied extensively in preclinical and in vitro research models. It is primarily researched for its role in tissue repair, collagen synthesis, wound healing, gene expression modulation, hair follicle biology, and antioxidant defense pathways.
Lyophilized means the compound has been freeze-dried — water is removed under vacuum to produce a stable powder. This process significantly extends shelf life and preserves compound integrity during storage and shipping. Lyophilized peptides are the research-grade standard because they maintain purity far longer than liquid formulations.
Each batch of GHK-Cu is independently verified at ≥99% purity using HPLC (High-Performance Liquid Chromatography). Identity is further confirmed by LC-MS (Liquid Chromatography-Mass Spectrometry). A batch-specific Certificate of Analysis (COA) is available for download before purchase.
Store lyophilized GHK-Cu at −20°C upon receipt. Keep protected from light, heat, and moisture. Do not open the vial until needed for your research protocol. Under proper storage conditions, lyophilized GHK-Cu maintains compound integrity for up to 24 months.
No. Peptides Verse does not provide reconstitution, dosing, or administration guidance of any kind. All reconstitution protocols are the sole responsibility of the qualified researcher or institution receiving this compound. This product is strictly for in vitro and laboratory research use only.
Yes. A batch-specific COA is available for every vial of GHK-Cu sold by Peptides Verse. The COA includes HPLC purity data, LC-MS identity confirmation, lot number, and testing lab details. It can be downloaded directly from the product page before or after purchase.
GHK refers to the free tripeptide (Glycyl-L-Histidyl-L-Lysine) without copper. GHK-Cu is the copper-chelated form — where a Cu² ion is bound to the tripeptide. The copper-chelated form is the biologically active version studied in most published research on wound healing, collagen synthesis, and gene expression modulation.
No. GHK-Cu from Peptides Verse is strictly for in vitro research and laboratory experimentation only. It is not intended for human or animal use of any kind. By purchasing, the buyer confirms they are a qualified researcher or institution and accepts full responsibility for safe handling and use.
All orders are shipped via FedEx with temperature-appropriate packaging to protect compound integrity during transit. Packaging is discreet — plain FedEx or UPS with no product branding on the exterior. Orders placed before 2 PM EST ship same business day.
Due to the nature of research chemicals, all sales are final once a vial has been opened or the seal broken. If you receive a damaged or incorrect item, contact support@peptidesverse.com within 48 hours of delivery with your order number and photos.