Molecular Weight: ~342 Da | Tripeptide (Lys-Pro-Val) | Form: Lyophilized | Purity: 99%+ HPLC
KPV is a short anti-inflammatory tripeptide (Lysine-Proline-Valine) — the C-terminal fragment of α-MSH (alpha-melanocyte-stimulating hormone). In preclinical and in-vitro research, KPV is documented for entering cells and downregulating NF-κB and MAPK signaling, reducing pro-inflammatory cytokines (TNF-α, IL-6) — making it a leading compound in inflammation, gut-barrier, and tissue-repair research. It retains α-MSH’s antiinflammatory activity without pigmentation effects. Each vial contains 10mg of lyophilized KPV at 99%+ HPLC-verified purity, with a batch-specific Certificate of Analysis available for download. *
KPV
Lysine-Proline-Valine tripeptide
Mechanism of Action• Intracellular Uptake: enters cells via PepT1 peptide transporters, allowing it to act on intracellular signaling.
• NF-κB & MAPK Inhibition: downregulates NF-κB and MAPK signaling, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) in cell models.
• Gut-Barrier & Immune Modulation: studied for supporting intestinal-barrier integrity and modulating immune responses in inflammation models.
Together these make KPV a key tool in inflammation, gut-barrier, and tissue-repair research.
| Compound | KPV (Lysine-Proline-Valine tripeptide) |
| Amino Acid Sequence | Lys-Pro-Val (K-P-V) |
| Amino Acids | 3 (tripeptide) |
| Type | α-MSH (11–13) C-terminal fragment |
| Molecular Weight | ~342 g/mol |
| CAS Number | Per batch COA |
| Origin | C-terminal tripeptide of α-melanocyte-stimulating hormone |
| Purity | ≥ 99% by HPLC |
| Identity | Confirmed by LC-MS |
| Form | Lyophilized powder |
| Vial Size / Sizes | 3mL glass vial · 5mg / 10mg |
| Fillers / Additives | None |
| Batch COA | Available for download |
- Inflammation & cytokine-signaling pathway research
- Gut-barrier & intestinal-inflammation models
- Tissue-repair & wound-healing research
- Immunomodulation & mast-cell research
- Antimicrobial / antifungal research (in vitro)
- α-MSH receptor-pathway research
For research teams investigating inflammation, gut-barrier biology, and tissue repair.
Storage & HandlingStorage: store lyophilized powder at -20°C long term; once reconstituted, store at 4°C, protect from light and moisture.
Handling: research use only; handle by licensed, qualified professionals with PPE. Reconstitution chemistry is the sole responsibility of the receiving research institution.
FEATURED INGREDIENTS
All Ingredients
Anti-Inflammatory
Studied for downregulating NF-κB signaling and proinflammatory cytokines (TNF-α, IL-6).
α-MSH Derived
The C-terminal tripeptide of α-MSH — retaining its anti-inflammatory activity without pigmentation effects.
Gut & Tissue
Researched in gut-barrier, intestinal-inflammation, and tissue-repair models.
PRODUCT BENEFITS
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α-MSH C-Terminal Tripeptide The Lys-Pro-Val fragment of α-MSH — retaining its anti-inflammatory activity in a small, stable peptide without pigmentation effects.
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NF-κB Pathway Downregulation Studied for inhibiting NF-κB and MAPK signaling, lowering pro-inflammatory cytokines (TNF-α, IL-6, IL-1β).
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Gut & Intestinal Research Examined in colitis-type and gut-barrier models as a tool for intestinal-inflammation research.
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Tissue Repair & Wound Healing Researched for supporting tissue recovery and wound-closure pathways.
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Antimicrobial Properties Studied for in-vitro activity against certain bacteria and fungi (e.g. Candida).
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99%+ HPLC-Verified Purity Independently verified by third-party labs via HPLC and LC-MS; batch-specific COA and SDS available pre-purchase.
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KPV is the C-terminal tripeptide (Lys-Pro-Val) of α-MSH. It is studied for entering cells via PepT1 transporters and downregulating NF-κB and MAPK signaling — lowering pro-inflammatory cytokines and supporting gut-barrier integrity in inflammation and tissue-repair research.*
WHAT TO EXPECT
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
α-MSH C-Terminal Origin
KPV is the active C-terminal tripeptide of α-MSH, carrying the anti-inflammatory message of the parent hormone without its melanocyte (pigmentation) activity.
NF-κB & MAPK Pathways
Studied for entering cells and inhibiting NF-κB and MAPK signaling, lowering pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) in research models.
Gut-Barrier & Repair
Examined in intestinal-inflammation and gut-barrier models, and researched for tissue-repair and wound-healing pathways.
ALL DETAILS
- α-MSH C-Terminal Origin — KPV is the active C-terminal tripeptide of α-MSH, carrying the anti-inflammatory message of the parent hormone without its melanocyte (pigmentation) activity.
- NF-κB & MAPK Pathways — Studied for entering cells and inhibiting NF-κB and MAPK signaling, lowering pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) in research models.
- Gut-Barrier & Repair — Examined in intestinal-inflammation and gut-barrier models, and researched for tissue-repair and wound-healing pathways.
The "KPV" Peptide |
No fillers | No artificial additives | No excipients | 99%+ HPLC verified · batch COA | No repackaged imports | No human-use claims |
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KPV Peptide
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Other Peptide |
The "KPV" Peptide
| Compare to: | KPV Peptide |
Other Peptide |
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| No fillers | ||
| No artificial additives | ||
| No excipients | ||
| 99%+ HPLC verified · batch COA | ||
| No repackaged imports | ||
| No human-use claims |
FAQs
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring copper-binding tripeptide studied extensively in preclinical and in vitro research models. It is primarily researched for its role in tissue repair, collagen synthesis, wound healing, gene expression modulation, hair follicle biology, and antioxidant defense pathways.
Lyophilized means the compound has been freeze-dried — water is removed under vacuum to produce a stable powder. This process significantly extends shelf life and preserves compound integrity during storage and shipping. Lyophilized peptides are the research-grade standard because they maintain purity far longer than liquid formulations.
Each batch of GHK-Cu is independently verified at ≥99% purity using HPLC (High-Performance Liquid Chromatography). Identity is further confirmed by LC-MS (Liquid Chromatography-Mass Spectrometry). A batch-specific Certificate of Analysis (COA) is available for download before purchase.
Store lyophilized GHK-Cu at −20°C upon receipt. Keep protected from light, heat, and moisture. Do not open the vial until needed for your research protocol. Under proper storage conditions, lyophilized GHK-Cu maintains compound integrity for up to 24 months.
No. Peptides Verse does not provide reconstitution, dosing, or administration guidance of any kind. All reconstitution protocols are the sole responsibility of the qualified researcher or institution receiving this compound. This product is strictly for in vitro and laboratory research use only.
Yes. A batch-specific COA is available for every vial of GHK-Cu sold by Peptides Verse. The COA includes HPLC purity data, LC-MS identity confirmation, lot number, and testing lab details. It can be downloaded directly from the product page before or after purchase.
GHK refers to the free tripeptide (Glycyl-L-Histidyl-L-Lysine) without copper. GHK-Cu is the copper-chelated form — where a Cu² ion is bound to the tripeptide. The copper-chelated form is the biologically active version studied in most published research on wound healing, collagen synthesis, and gene expression modulation.
No. GHK-Cu from Peptides Verse is strictly for in vitro research and laboratory experimentation only. It is not intended for human or animal use of any kind. By purchasing, the buyer confirms they are a qualified researcher or institution and accepts full responsibility for safe handling and use.
All orders are shipped via FedEx with temperature-appropriate packaging to protect compound integrity during transit. Packaging is discreet — plain FedEx or UPS with no product branding on the exterior. Orders placed before 2 PM EST ship same business day.
Due to the nature of research chemicals, all sales are final once a vial has been opened or the seal broken. If you receive a damaged or incorrect item, contact support@peptidesverse.com within 48 hours of delivery with your order number and photos.