MW: 854.99 g/mol | 7 Amino Acids | ACTH(4-10) Analogue | Form: Lyophilized | Purity: 99%+ HPLC
Semax is a 7-amino-acid synthetic analogue of ACTH(4-10), the 4-10 fragment of adrenocorticotropic hormone, with a C-terminal Pro-Gly-Pro extension that enhances its stability and neuroprotective profile. In preclinical and in-vitro research, Semax is documented for BDNF upregulation in the hippocampus, neuroprotection pathway research, Default Mode Network (DMN) activation, IL-6 cytokine suppression, and enkephalin protection — making it one of the most versatile neuropeptides in neurological and immunepathway research. Each vial contains 10mg of lyophilized Semax at 99%+ HPLC-verified purity, with a batch-specific Certificate of Analysis available for download. *
Semax
ACTH(4-10) Synthetic Analogue
Mechanism of Action• BDNF Upregulation & Neuroplasticity: studied for increasing brain-derived neurotrophic factor (BDNF) in the hippocampus, supporting neuroplasticity, memory formation, and brain-cell resilience in neurological research models.
• Neuroprotection & Vascular Pathway Research: studied in ischemic research models for activating vascular-function genes, promoting neurogenesis pathways, and protecting neurons from ischemic damage.
• Default Mode Network (DMN) Activation: fMRI studies suggest Semax activates the DMN — brain pathways governing social cognition, environmental awareness, and resting-state neural activity.
• IL-6 Suppression & Enkephalin Protection: researched for downregulating IL-6 cytokine and T-helper cell modulation, and for inhibiting enkephalin degradation in pain-pathway research models.
Together these make Semax one of the most versatile neuropeptides in neurological, cognitive-pathway, and immune research.
| Compound | Semax (ACTH(4-10) synthetic analogue) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro + C-terminal Pro-Gly-Pro extension (7 aa total) |
| Amino Acids | 7 |
| Origin | Synthetic analogue of ACTH(4-10) — fragment of adrenocorticotropic hormone residues 4-10 |
| Formula | C₃₉H₅₄N₁₀O₁₀S |
| MW | 854.99 g/mol |
| CAS Number | 80714-61-0 |
| Purity | ≥ 99% by HPLC |
| Identity | Confirmed by LC-MS |
| Form | Lyophilized powder |
| Vial Sizes | 3mL glass vial · 5mg / 10mg (separate SKUs) |
| Fillers / Additives | None |
| Batch COA | Available for download |
- BDNF upregulation & hippocampal neuroplasticity research
- Ischemic neuroprotection & vascular-gene activation research
- Default Mode Network (DMN) & cognitive pathway research
- IL-6 cytokine suppression & immune-modulation pathway research
- Serotonin & dopamine pathway modulation research
- Enkephalin protection & pain-pathway research models
For research teams investigating neuroprotection, BDNF pathways, and neurological research.
Storage & HandlingStorage: store lyophilized powder at -20°C long term; protect from light and moisture.
Handling: research use only; handle by licensed, qualified professionals with PPE.
FEATURED INGREDIENTS
All Ingredients
ACTH(4-10) Analogue
A 7-amino-acid synthetic analogue of ACTH residues 4-10, with a C-terminal Pro-Gly-Pro extension that enhances its stability and neurological research profile.
BDNF & Neuroprotection Research
Studied for increasing BDNF in the hippocampus — a protein linked to brain plasticity — and examined in ischemic and neuroprotection research models.
Brain Network Research
Studied for activating the Default Mode Network (DMN) — brain pathways involved in social cognition, awareness, and resting-state neural activity.
PRODUCT BENEFITS
-
ACTH(4-10) Synthetic Analogue 7-aa analogue of the ACTH(4-10) fragment with a C-terminal Pro-Gly-Pro extension — combining neuroprotective, cognitive-pathway, and immune-modulating research in one compact molecule.
-
BDNF Upregulation Research Studied for increasing BDNF (brain-derived neurotrophic factor) in the hippocampus — a key regulator of neuroplasticity, memory formation, and brain-cell resilience in research models.
-
Neuroprotection Research Examined in ischemic and neurological protection research models for how it may activate vascular genes and protect neurons from damage.
-
Default Mode Network Research Studied for activating the Default Mode Network (DMN) — brain pathways involved in social cognition, resting-state activity, and environmental awareness.
-
Immune & IL-6 Pathway Research Examined for modulating IL-6 cytokine levels and T-helper cell activity in immune-pathway and anti-inflammatory research models.
-
99%+ HPLC-Verified Purity Independently verified by third-party labs via HPLC and LC-MS; batch-specific COA and SDS available pre-purchase.
CUSTOMERS ALSO PURCHASED
GLP1-T · 15mg Tirzepatide · Dual Receptor Agonist (GLP-1 + GIP) · Metabolic Research
GLP1-S · 5mg Semaglutide · GLP-1 Receptor Agonist · Metabolic Research
MOTS-c 10mg Mitochondria-Derived Peptide
Cagrilintide · 10mg Long-Acting Amylin Analogue · Metabolic & Satiety Research
Loved by thousands
Bundle and save 20%
5-Amino-1MQ · 5mg NNMT Inhibitor · Small Molecule (Quinolinium) · Metabolic & NAD+ Research
- Daily Vitamin
- Probiotics
Semax is a 7-amino-acid ACTH(4-10) analogue studied across four simultaneous research pathways — making it one of the most versatile neuropeptides in preclinical research. It boosts BDNF for neuroplasticity research, activates the Default Mode Network for brain-circuit studies, suppresses IL-6 for immune research, and protects enkephalins for opioid-system studies — all in a single compact molecule.*
WHAT TO EXPECT
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
BDNF Upregulation & Neuroplasticity
Studied for increasing brain-derived neurotrophic factor (BDNF) in the hippocampus, supporting neuroplasticity, memory-formation pathways, and brain-cell resilience in neurological research models. Also researched in ischemic models for activating vascular-function genes and protecting neurons from damage.
Default Mode Network & Cognitive Pathway Research
Functional MRI studies suggest Semax activates the Default Mode Network (DMN) — brain pathways governing social cognition, environmental awareness, and resting-state activity. Also studied for serotonin and dopamine pathway modulation in cognitive research models.
IL-6 Suppression, Immune Modulation & Enkephalin Protection
Researched for downregulating IL-6 (a pro-inflammatory cytokine) and regulating T-helper cell activity in immune-pathway research, and for inhibiting enkephalin degradation — protecting the body’s naturally occurring pain modulators in opioid-system pathway research.
ALL DETAILS
- BDNF Upregulation & Neuroplasticity — Studied for increasing brain-derived neurotrophic factor (BDNF) in the hippocampus, supporting neuroplasticity, memory-formation pathways, and brain-cell resilience in neurological research models. Also researched in ischemic models for activating vascular-function genes and protecting neurons from damage.
- Default Mode Network & Cognitive Pathway Research — Functional MRI studies suggest Semax activates the Default Mode Network (DMN) — brain pathways governing social cognition, environmental awareness, and resting-state activity. Also studied for serotonin and dopamine pathway modulation in cognitive research models.
- IL-6 Suppression, Immune Modulation & Enkephalin Protection — Researched for downregulating IL-6 (a pro-inflammatory cytokine) and regulating T-helper cell activity in immune-pathway research, and for inhibiting enkephalin degradation — protecting the body’s naturally occurring pain modulators in opioid-system pathway research.
The "Semax" Peptide |
No fillers | No artificial additives | No excipients | 99%+ HPLC verified · batch COA | No repackaged imports | No human-use claims |
|---|---|---|---|---|---|---|
|
Semax Peptide
|
||||||
Other Peptide |
The "Semax" Peptide
| Compare to: | Semax Peptide |
Other Peptide |
|---|---|---|
| No fillers | ||
| No artificial additives | ||
| No excipients | ||
| 99%+ HPLC verified · batch COA | ||
| No repackaged imports | ||
| No human-use claims |
FAQs
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring copper-binding tripeptide studied extensively in preclinical and in vitro research models. It is primarily researched for its role in tissue repair, collagen synthesis, wound healing, gene expression modulation, hair follicle biology, and antioxidant defense pathways.
Lyophilized means the compound has been freeze-dried — water is removed under vacuum to produce a stable powder. This process significantly extends shelf life and preserves compound integrity during storage and shipping. Lyophilized peptides are the research-grade standard because they maintain purity far longer than liquid formulations.
Each batch of GHK-Cu is independently verified at ≥99% purity using HPLC (High-Performance Liquid Chromatography). Identity is further confirmed by LC-MS (Liquid Chromatography-Mass Spectrometry). A batch-specific Certificate of Analysis (COA) is available for download before purchase.
Store lyophilized GHK-Cu at −20°C upon receipt. Keep protected from light, heat, and moisture. Do not open the vial until needed for your research protocol. Under proper storage conditions, lyophilized GHK-Cu maintains compound integrity for up to 24 months.
No. Peptides Verse does not provide reconstitution, dosing, or administration guidance of any kind. All reconstitution protocols are the sole responsibility of the qualified researcher or institution receiving this compound. This product is strictly for in vitro and laboratory research use only.
Yes. A batch-specific COA is available for every vial of GHK-Cu sold by Peptides Verse. The COA includes HPLC purity data, LC-MS identity confirmation, lot number, and testing lab details. It can be downloaded directly from the product page before or after purchase.
GHK refers to the free tripeptide (Glycyl-L-Histidyl-L-Lysine) without copper. GHK-Cu is the copper-chelated form — where a Cu² ion is bound to the tripeptide. The copper-chelated form is the biologically active version studied in most published research on wound healing, collagen synthesis, and gene expression modulation.
No. GHK-Cu from Peptides Verse is strictly for in vitro research and laboratory experimentation only. It is not intended for human or animal use of any kind. By purchasing, the buyer confirms they are a qualified researcher or institution and accepts full responsibility for safe handling and use.
All orders are shipped via FedEx with temperature-appropriate packaging to protect compound integrity during transit. Packaging is discreet — plain FedEx or UPS with no product branding on the exterior. Orders placed before 2 PM EST ship same business day.
Due to the nature of research chemicals, all sales are final once a vial has been opened or the seal broken. If you receive a damaged or incorrect item, contact support@peptidesverse.com within 48 hours of delivery with your order number and photos.