Compound Class: NNMT Inhibitor / Quinolinium Derivative | Form: Lyophilized powder | Purity: ≥99% HPLC | NOT a peptide
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small-molecule compound from the quinolinium chemical class — NOT a peptide. It is a selective inhibitor of nicotinamide Nmethyltransferase (NNMT), the enzyme that methylates nicotinamide to form 1- methylnicotinamide (1-MNA). By inhibiting NNMT, 5-Amino-1MQ preserves nicotinamide for NAD+ synthesis, studied for elevating intracellular NAD+, activating sirtuin enzymes, modulating adipose tissue metabolism, and influencing histone methylation in preclinical metabolic and oncology research models. Each vial contains 5mg of lyophilized 5-Amino1MQ at 99%+ HPLC-verified purity, with a batch-specific Certificate of Analysis available for download. *
5-Amino-1MQ
5-Amino-1-methylquinolinium (Selective NNMT Inhibitor)
Mechanism of Action• NNMT Inhibition → Nicotinamide Preservation: blocks NNMT from methylating nicotinamide to 1-MNA — preserving nicotinamide for NAD+ biosynthesis via the salvage pathway.
• NAD+ Elevation → Sirtuin Activation: elevated intracellular NAD+ activates sirtuin enzymes (SIRT1/SIRT3) — key regulators of mitochondrial function, oxidative metabolism, and longevity pathway research.
• Adipose Tissue Metabolism Research: NNMT is highly expressed in adipose tissue. Preclinical murine models showed reductions in adipocyte size and white adipose mass without changes in food intake — suggesting direct metabolic modulation via energy expenditure pathways rather than appetite suppression.
• SAM Depletion → Histone Methylation Modulation: NNMT inhibition reduces availability of SAM (S-adenosylmethionine) — the methyl donor — studied for modifying histone methylation patterns in cancer-associated fibroblast (CAF) models and oncogenesis research.
Together these make 5-Amino-1MQ a key tool in NNMT enzyme biology, NAD+ pathway, adipose tissue metabolism, and oncology research.
| Compound | 5-Amino-1MQ (5-Amino-1-methylquinolinium) |
| Compound Class | Quinolinium derivative — synthetic small molecule (NOT a peptide) |
| Full IUPAC Name | 5-amino-1-methylquinolin-1-ium (iodide salt form common in research) |
| Synonyms | 5-Amino-1-methylquinolinium · 5A1MQ · 5-AMQ |
| Mechanism | Selective NNMT (nicotinamide N-methyltransferase) inhibitor |
| Purity | ≥ 99% by HPLC |
| Identity | Confirmed by LC-MS |
| Form | Lyophilized powder |
| Vial Size | Sealed vial · 5mg (verify if 10mg also available) |
| Note | CAS and MW: verify vs batch COA — varies by salt form (free base vs iodide) |
| Fillers / Additives | None |
| Batch COA | Available for download |
5-Amino-1MQ is studied across multiple preclinical research areas:
- NNMT enzyme inhibition & nicotinamide methylation pathway research
- Intracellular NAD+ elevation & NAD+ salvage pathway research
- Sirtuin activation & longevity pathway research
- Adipose tissue metabolism & energy expenditure pathway research
- Histone methylation & SAM-pathway oncology research models
- Cancer-associated fibroblast (CAF) pathway research
For research teams investigating NNMT enzyme biology, NAD+ metabolism, and metabolic pathway regulation.
Storage & HandlingStorage: Store lyophilized powder at -20°C long term; protect from light and moisture. Stable at room temperature for short-term shipping; refrigeration recommended upon receipt.
Handling: Research use only; handle by licensed, qualified professionals with appropriate chemical-safety PPE. Dispose of according to institutional chemical waste disposal protocols.
FEATURED INGREDIENTS
All Ingredients
Selective NNMT Inhibitor
A synthetic quinolinium-class small molecule that selectively blocks the NNMT enzyme from methylating nicotinamide — preserving it for NAD+ synthesis.
NAD+ Elevation Research
Studied for increasing intracellular NAD+ by preserving nicotinamide — linking it to sirtuin activation, mitochondrial function, and cellular energy research.
Adipose & Metabolic Research
NNMT is highly expressed in adipose tissue. Studied for effects on adipocyte size, energy expenditure pathways — without appetite-suppression mechanisms.
PRODUCT BENEFITS
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Selective NNMT Inhibitor A synthetic quinolinium-class small molecule that selectively inhibits NNMT — the enzyme that consumes nicotinamide via methylation. Inhibiting NNMT preserves nicotinamide for NAD+ biosynthesis.
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NAD+ Elevation Research Studied for increasing intracellular NAD+ levels by blocking NNMT-driven nicotinamide methylation — linking it to the broader NAD+ and sirtuin research ecosystem.
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Adipose Tissue & Energy Pathway Research NNMT is expressed abundantly in adipose tissue. Studies in murine obesity models showed 5-Amino-1MQ effects on adipocyte size, white adipose mass, and energy expenditure — without changes in food intake.
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Sirtuin Activation & Longevity Research Studied for how elevated NAD+ from NNMT inhibition activates sirtuin enzymes (SIRT1/SIRT3), which regulate mitochondrial function, epigenetics, and metabolic regulation.
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Oncology & Histone Methylation Research NNMT inhibition reduces SAM (S-adenosylmethionine) availability, studied for modulating histone methylation in cancer-associated fibroblast (CAF) models and oncogenesis pathway research.
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99%+ HPLC-Verified Purity Independently verified by third-party labs via HPLC and LC-MS; batch-specific COA and SDS available pre-purchase.
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5-Amino-1MQ · 5mg NNMT Inhibitor · Small Molecule (Quinolinium) · Metabolic & NAD+ Research
- Daily Vitamin
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5-Amino-1MQ is a small-molecule enzyme inhibitor — it blocks NNMT, the enzyme that “wastes” nicotinamide by turning it into 1-MNA. By blocking NNMT, more nicotinamide stays available for NAD+ synthesis. Higher NAD+ activates sirtuin enzymes, supports mitochondrial function, and is studied for effects on adipose tissue energy pathways — all without influencing appetite or food intake in preclinical models.*
WHAT TO EXPECT
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
NNMT Inhibition & NAD+ Elevation
Blocks NNMT from methylating nicotinamide to 1-MNA (1-methylnicotinamide), preserving nicotinamide for the NAD+ salvage pathway. Elevated NAD+ then activates sirtuin enzymes (SIRT1/SIRT3) — key regulators of mitochondrial function, metabolic signalling, and longevity pathway research.
Adipose Tissue & Energy Expenditure Research
NNMT is highly expressed in adipose tissue, where it regulates fat cell size and lipid storage dynamics. Preclinical murine models showed effects on adipocyte size and white adipose mass without changes in food intake — suggesting metabolic modulation via energy expenditure pathways rather than appetite suppression.
Histone Methylation & Oncology Research
NNMT inhibition depletes SAM (S-adenosylmethionine), the methyl donor — studied for modulating histone methylation patterns in cancer-associated fibroblast (CAF) models and oncogenesis pathway research.
ALL DETAILS
- NNMT Inhibition → Nicotinamide Preservation → NAD+ Elevation — Blocks NNMT from methylating nicotinamide to 1-MNA (1-methylnicotinamide), preserving nicotinamide for the NAD+ salvage pathway. Elevated NAD+ then activates sirtuin enzymes (SIRT1/SIRT3) — key regulators of mitochondrial function, metabolic signalling, and longevity pathway research.
- Adipose Tissue & Energy Expenditure Research — NNMT is highly expressed in adipose tissue, where it regulates fat cell size and lipid storage dynamics. Preclinical murine models showed effects on adipocyte size and white adipose mass without changes in food intake — suggesting metabolic modulation via energy expenditure pathways rather than appetite suppression.
- Histone Methylation & Oncology Research — NNMT inhibition depletes SAM (S-adenosylmethionine), the methyl donor — studied for modulating histone methylation patterns in cancer-associated fibroblast (CAF) models and oncogenesis pathway research.
The "5-Amino-1MQ" Peptide |
No fillers | No artificial additives | No excipients | 99%+ HPLC verified · batch COA | No repackaged imports | No human-use claims |
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5-Amino-1MQ Peptide
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Other Peptide |
The "5-Amino-1MQ" Peptide
| Compare to: | 5-Amino-1MQ Peptide |
Other Peptide |
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| No fillers | ||
| No artificial additives | ||
| No excipients | ||
| 99%+ HPLC verified · batch COA | ||
| No repackaged imports | ||
| No human-use claims |
FAQs
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring copper-binding tripeptide studied extensively in preclinical and in vitro research models. It is primarily researched for its role in tissue repair, collagen synthesis, wound healing, gene expression modulation, hair follicle biology, and antioxidant defense pathways.
Lyophilized means the compound has been freeze-dried — water is removed under vacuum to produce a stable powder. This process significantly extends shelf life and preserves compound integrity during storage and shipping. Lyophilized peptides are the research-grade standard because they maintain purity far longer than liquid formulations.
Each batch of GHK-Cu is independently verified at ≥99% purity using HPLC (High-Performance Liquid Chromatography). Identity is further confirmed by LC-MS (Liquid Chromatography-Mass Spectrometry). A batch-specific Certificate of Analysis (COA) is available for download before purchase.
Store lyophilized GHK-Cu at −20°C upon receipt. Keep protected from light, heat, and moisture. Do not open the vial until needed for your research protocol. Under proper storage conditions, lyophilized GHK-Cu maintains compound integrity for up to 24 months.
No. Peptides Verse does not provide reconstitution, dosing, or administration guidance of any kind. All reconstitution protocols are the sole responsibility of the qualified researcher or institution receiving this compound. This product is strictly for in vitro and laboratory research use only.
Yes. A batch-specific COA is available for every vial of GHK-Cu sold by Peptides Verse. The COA includes HPLC purity data, LC-MS identity confirmation, lot number, and testing lab details. It can be downloaded directly from the product page before or after purchase.
GHK refers to the free tripeptide (Glycyl-L-Histidyl-L-Lysine) without copper. GHK-Cu is the copper-chelated form — where a Cu² ion is bound to the tripeptide. The copper-chelated form is the biologically active version studied in most published research on wound healing, collagen synthesis, and gene expression modulation.
No. GHK-Cu from Peptides Verse is strictly for in vitro research and laboratory experimentation only. It is not intended for human or animal use of any kind. By purchasing, the buyer confirms they are a qualified researcher or institution and accepts full responsibility for safe handling and use.
All orders are shipped via FedEx with temperature-appropriate packaging to protect compound integrity during transit. Packaging is discreet — plain FedEx or UPS with no product branding on the exterior. Orders placed before 2 PM EST ship same business day.
Due to the nature of research chemicals, all sales are final once a vial has been opened or the seal broken. If you receive a damaged or incorrect item, contact support@peptidesverse.com within 48 hours of delivery with your order number and photos.